I= PHYTOCHEMICAL INVESTIGATION ON THE CHEMICAL CONSTITUENTS OF SARCOCOCCA SALIGANA, FICUS RELIGIOSA AND RELATED MEDICINAL PLANTS AND SYNTHETIC STUDIES TOWARDS INTERESTING NEW HETEROCYCLIC COMPOUNDS
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Title of Thesis
PHYTOCHEMICAL INVESTIGATION ON THE CHEMICAL CONSTITUENTS OF SARCOCOCCA SALIGANA, FICUS RELIGIOSA AND RELATED MEDICINAL PLANTS AND SYNTHETIC STUDIES TOWARDS INTERESTING NEW HETEROCYCLIC COMPOUNDS

Author(s)
Fareeda Feroz
Institute/University/Department Details
University of Karachi, Pakistan
Session
2004
Subject
Chemistry
Number of Pages
223
Keywords (Extracted from title, table of contents and abstract of thesis)
sarcococca saligana, ficus religiosa, medicinal plants, heterocyclic compounds, pregnane-type steroidal alkaloids, antileishmanial activity

Abstract
Part A: Bioassay-guided isolation of cholinesterase inhibiting pregnane-type steroidal alkaloids from sarcococca saligna (D. Don.) Muell., afforded nine new and ten known pregnane-type steroidal alkaloids from the chloroform extract of the plant. The cholinesterase inhibiting of these compounds were carried out by Mr. Sarfraz Ahmad Nawaz in the Enzyme inhibition Laboratory of the Institute.

All compounds were found to possess a varying degree of cholinesterase inhibitory potential in a concentration-dependent manner with the IC50 values ranging from 12.5-200 um against acetylcholinesterae and 1.25-25.0 um against butyryl- cholinesterase

New Alkaloids Isolated from Sarcococca Saligna.

Known Alkaloids Isolated from Sarcococca Saligna.

Part B: The part B of the thesis contains of the bioassay-guided isolation of five antileishmanial constituents from Ficus religiosa Linn, for the first time from this species. Known compounds Isolated from Ficus religiosa.

Subfractions of the plant pure compounds were evaluated for antileishmanial activity by Mrs. Farhana Khukab in the bioassay section of the Institute.

Part C: part c focuses on the synthesis of the fused heterocyclic ring with quinoxaline and benzimidazole moieties, accomplished on the basis of our previously reported arrangement of anthranilopapavarine and B-carbline systems, either by thermolysis or pyrolysis.

The structures of compounds isolated from the sarcococca saligna and Ficus religiosa were elucidated through spectroscopic methods using UV, 1H-and 13 C-NMR and 2D-NMR techniques (COSY, NOESY, NOE, HMQC). Spectroscopic techniques were also employed for the structural identification of synthetic compounds.

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S. No. Chapter Title of the Chapters Page Size (KB)
1 1 General Introduction 1
116.78 KB
2 2 Studies On The Chemical Constituents Of Sarcococca Saligna 5
3874.36 KB
  2.1 Introduction 5
  2.2 Biosynthesis Of Sarcococca Alkaliods 14
  2.3 Spectral Generalizations Of Sarcococca Alkaloids 22
  2.4 Phytochemical Investigations On Sarcococca Saligna 27
  2.5 Results And Discussion 31
3 3 Studies On The Chemical Constituents Of Ficus Religiosa 115
424.68 KB
  3.1 Introduction 115
  3.2 Results And Discussion 116
  3.3 Antileishmanial Activity Of Compounds Isolated From Ficus Religiosa 123
4 4 Synthesis And Rearrangement Of Heterocyclic Compounds 130
592.64 KB
  4.1 Introduction 130
  4.2 Results And Discussion 136
5 5 Experimental 148
1632.47 KB
  5.1 General Experimental Conditions 148
  5.2 Sarcococca Saligna 149
  5.3 Ficus Religiosa 176
  5.4 Synthesis And Rearrangement Of Heterocyclic Compounds 183
  5.5 Biological Activities 187
6 6 Bibliography 194
321.27 KB
7 7 Glossary 204
53.83 KB
8 8 List Of Publications 207
58.25 KB