I= PHYTOCHEMICAL INVESTIGATIONS ON THE CONSTITUENTS OF BUXUS PAPILLOSA AND RELATED MEDICINAL PLANTS
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Title of Thesis
PHYTOCHEMICAL INVESTIGATIONS ON THE CONSTITUENTS OF BUXUS PAPILLOSA AND RELATED MEDICINAL PLANTS

Author(s)
Bakht Baidar Ali
Institute/University/Department Details
Institute of Chemistry University of the Punjab, Lahore
Session
1994
Subject
Chemistry
Number of Pages
245
Keywords (Extracted from title, table of contents and abstract of thesis)
buxus papillosa, medicinal plants, buxus sempervirens, adhatoda vasica, antifungal activity, antibacterial activity, nematocidal activity, steroidal alkaloids, quinazoline alkaloids

Abstract
This thesis includes the work on three medicinal plants i.e Buxus papillosa, Buxus Sempervirens and Adhatoda vasica.

The firs part of this thesis includes the work on chemical constituents of leaves of Buxus papillosa and have resulted in the isolation of two new alkaloid, alongwith a new terpenoidal compound. While two other compounds are going to be reported fro the first time from the Buxaceae family. Four known alkaloids have also been isolated.

1N-Benzoyl-6-acetylbuxabenzamine 2Buxus benzapapilinine 3Buxapapilodiol 4Methy-3-hydroxy-4-methoxybenzoate 5Methyl-4-hydroxy-3, 5-dimethoxybenzoate

Known alkaloids 1Cyclomicrobuxinine 2(-)-E-Buxenone 3Irehine 4Moenjodaramine

Part-2 of this thesis deals with the chemical constituents isolated from the leaves of Buxus sempervirens and have resulted in the isolation of following two compounds of which one is new and other one is known.

New compound (i)5,8-Dimethoxy-7-glucopyranosyloxy-cis-cinnamie acid

Known compound (i)β-Zoosterol

Part-3 of this thesis includes the isolation and characterization of bio-active alkaloidal constituents from the leaves of Adhatoda vasica and have resulted in the isolated of four known basis, they were characterized by using modern 2D-NMR techniques for the first time, and they were subjected for screening antifungal, antibacterial and nematocidal activity. It was founded that these compounds exhibited good antifungal, antibacterial and nematocidal activity. These four bases are:

(i)Vasicinone (ii)Vasicolinone (iii)Vasicine (iv)Vasicol

Extensive spectroscopic techniques such as EIMS, FDMS, FABMS, HRMS, UV, IR, 1H and 13C-NME (BB, BEPT) COSY-45o, J-resolved, TOCS, HMBC and HMQC were employed to elucidate the structures of the above compounds.

Download Full Thesis
1465.09 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
90.86 KB
2 1 General Introduction 7
36.13 KB
3 2 Introduction
524.71 KB
 
  2.1 Alkaloids 15
  2.2 Classification of alkaloids 19
  2.3 Steroidal alkaloids 19
4 3 Experimental 110
157.02 KB
  3.1 General Experimental conditions 111
  3.2 Separation techniques 111
  3.3 Plant Material of Buxus papillosa 116
5 4 Results and discussion 132
228.52 KB
  4.1 Isolation of the compounds from the leaves of Buxus papillosa 133
6 5 Compounds from the leaves of Buxus Sempervirens 162
100.05 KB
  5.1 Introduction 163
  5.2 Biosynthesis of cinnamic acid 165
  5.3 Experimental 167
  5.4 Results and discussion 173
7 6 General introduction 180
293.68 KB
  6.1 Introduction 181
  6.2 Pharmacology of quinazoline Alkaloids 181
  6.3 Uses in indigenous system of medicine 182
  6.4 Experimental 183
  6.5 Results and discussion 191
  6.6 Biological activity of pure compounds and crude extracts of adhatoda vasica 199
  6.7 References