This thesis includes the work on three medicinal plants i.e Buxus papillosa, Buxus Sempervirens and Adhatoda vasica.
The firs part of this thesis includes the work on chemical constituents of leaves of Buxus papillosa and have resulted in the isolation of two new alkaloid, alongwith a new terpenoidal compound. While two other compounds are going to be reported fro the first time from the Buxaceae family. Four known alkaloids have also been isolated.
1N-Benzoyl-6-acetylbuxabenzamine 2Buxus benzapapilinine 3Buxapapilodiol 4Methy-3-hydroxy-4-methoxybenzoate 5Methyl-4-hydroxy-3, 5-dimethoxybenzoate
Known alkaloids 1Cyclomicrobuxinine 2(-)-E-Buxenone 3Irehine 4Moenjodaramine
Part-2 of this thesis deals with the chemical constituents isolated from the leaves of Buxus sempervirens and have resulted in the isolation of following two compounds of which one is new and other one is known.
New compound (i)5,8-Dimethoxy-7-glucopyranosyloxy-cis-cinnamie acid
Known compound (i)β-Zoosterol
Part-3 of this thesis includes the isolation and characterization of bio-active alkaloidal constituents from the leaves of Adhatoda vasica and have resulted in the isolated of four known basis, they were characterized by using modern 2D-NMR techniques for the first time, and they were subjected for screening antifungal, antibacterial and nematocidal activity. It was founded that these compounds exhibited good antifungal, antibacterial and nematocidal activity. These four bases are:
(i)Vasicinone (ii)Vasicolinone (iii)Vasicine (iv)Vasicol
Extensive spectroscopic techniques such as EIMS, FDMS, FABMS, HRMS, UV, IR, 1H and 13C-NME (BB, BEPT) COSY-45o, J-resolved, TOCS, HMBC and HMQC were employed to elucidate the structures of the above compounds.