I= SYNTHESIS AND EVALUATION OF N, N-DIALKYLBENZYLAMINES AND THEIR DERIVATIVES WITH IB AND IIB METALS
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Title of Thesis
SYNTHESIS AND EVALUATION OF N, N-DIALKYLBENZYLAMINES AND THEIR DERIVATIVES WITH IB AND IIB METALS

Author(s)
Hafiz Muhammad Farooq
Institute/University/Department Details
Institute of Chemistry, University of the Punjab, Quaid-E-Azam Campus, Lahore
Session
2001
Subject
Chemistry
Number of Pages
310
Keywords (Extracted from title, table of contents and abstract of thesis)
N-dialkylbenzylamines, Chelates, Pathogenic Bacteria Fungus, ligands, Bacillus subtilis, Escherichia coli, Micrococcus luteus, Staphylococcus aureus, Aspergillus flavus

Abstract
N, N-dialkylbenzylamines and their ortho and meta substituted derivatives were synthesized by indirect bromination of toluenes and substituted toluenes with N-bromosuccinimide in CCI4 using benzoyl peroxide as catalyst to allowed by the addition of secondary amines. They were separated by filtration. separating funnel and then by column chromatography. They were dried by rotary evaporator. The purity of these compounds was checked by thin layer chromatography (T.L.C.). Physical parameters such as melting/boiling/decomposition points, ╬╗max, refractive Index, viscosity, surface tension, relative density etc. were also determined by using commonly known methods for these new reagents as yet not reported in literature.

N, N-dialkylbenzylamines were' evaluated on the basis of chemical characteristics. analytical data and spectroscopic techniques such as uv-visible spectroscopy. elemental analysis, infrared (IR) spectroscopy, nuclear magnetic resonance (NMR) and electron impact mass spectrometry (ElMS). Single crystal XRD analysis of o-nitro-N,N-dicyclohexylbenzylamine (a crystalline solid) was also. performed for the determination of structure,

Complexes of. these substituted benzylamines with Cu(II), Ag(I), Au(III), Zn(II), Cd(lI) and Hg(lI) were synthesized in an ethanol water mixture. The complexes were' separated, washed and dried. They were found to be in-soluble in most of the organic solvents. Their melting/decomposition points were determined by Gallen kamp M.P. apparatus. Empirical formulas of N,N-dialkylbenzylamines and their metal complexes on the basis of analytical data are given in the Tables 3.1.5 A to 3.1.5 I. Characterization of these complexes was made on the basis of infrared (IR) spectroscopy, atomic absorption spectroscopy (AAS), elemental analysis and X-ray diffraction studies.

Thermogravimetric (TG) and differential thermal analyses (DTA) of complexes were performed in order to study relative thermal stabilities and decomposition patterns of the complexes.

The ligands and their complexes were also screened for antibacterial and antifungal activities by the diffusion plate method against the four pathogenic bacteria, Bacillus subtilis (B.s), Escherichia coli (E.c) Micrococcus luteus (M.I) and Staphylococcus aureus (S.a) and a fungus, Aspergillus flavus respectively.

Download Full Thesis
39113.27 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
3053.51 KB
2 1 Introduction 1-6
1033.16 KB
  1.1 Toxicity Of Amines
  1.2 Medicinal Significance Of Transition Metals
  1.3 Medicinal Significance Of Chelates
3 2 Literature Survey 7-13
1326.45 KB
4 3 Synthesis And Evaluation Of N, N-Dialkylbenzylamines And Their Metal Complexes 14-130
17690.38 KB
  3.1 Materials And Methods
  3.2 Synthesis Of N, N-Dialkylbenzylamines 22
  3.3 Synthesis Of Metal Complexes 52
  3.4 Results And Discussion
5 4 Thermoravimetric And Differential Thermal Analysis 131
5148.26 KB
  4.1 Materials And Methods
  4.2 Residual Analysis
  4.3 Results And Discussion
6 5 X-Ray Diffraction Studies 184
7782.98 KB
  5.1 Materials And Methods
  5.2 Qualitative Analysis
  5.3 Single Crystal Xrd Analysis
  5.4 Results And Discussion
7 6 Anti-Bacteria And Anti-Fugal Activity 264
1637.96 KB
  6.1 Pathogenic Bacteria Fungus
  6.2 Materials And Methods
  6.3 Results And Discussion
  6.4 Conclusion
8 7 Bibliography 275
1425.26 KB
  7.1 List Of Publications 283