I= CUMULATIVE TOXICITIES OF COMMONLY USED ANALGESIC, CO-ANALGESIC AND ANTINEOPLASTIC DRUGS
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Title of Thesis
CUMULATIVE TOXICITIES OF COMMONLY USED ANALGESIC, CO-ANALGESIC AND ANTINEOPLASTIC DRUGS

Author(s)
Rafeeq Alam Khan
Institute/University/Department Details
University Of Karachi/ Department Of Pharmacology
Session
1995
Subject
Pharmacy
Number of Pages
227
Keywords (Extracted from title, table of contents and abstract of thesis)
analgesic drugs, co-analgesic drugs, antineoplastic drugs, cancer, anticancer therapy, cyclophossphamide-buprenorphine-diazepam, 5-fluorouracil-buprenorphine-diazepam, 5-fluorouracil-paracetamol-nalbuphine-diazepam, toxicity, paracetamol-nalbuphine-diazepam, anticancer drugs

Abstract
A review of the published data about cancer reveals that incidence of cancer is likely to be increased over the next decade, similarly a number of surveys also indicate that cancer and pain always co-exist, this co-existence of pain with cancer necessitate the administration of multiple analgesic drugs with anticancer therapy to patients, which greatly increases the risk of drug toxicities in person already living in miserable conditions, occasionally these risks are predictable on the basis of known pharmacology of the drugs used, but all too often they have emerged only after the exposure of many patients, thus combinations require separate investigation with animal toxicity studies and clinical evaluation in as full a scrutiny as afforded to a completely new drug

Considering the prevailing alarming situation of cancer in Pakistan, present study is specifically designed to achieve multifold objectives such as to assess the toxicities of multiple drug administration, not to predict but rather to warn the users and prescribers, of the possible dangers, to discourage the use of combinations which have high cumulative toxicities in animals and to suggest a more useful combination in developing countries like Pakistan where patients have poor performance status and do not give response as can be expected by a particular combination

Present study in general has revealed that mortality is high in animals with marked decrease in hemoglobin level and erythrocyte count, therefore out of the nine combinations animal groups which received cyclophossphamide-buprenorphine-diazepam, 5-fluorouracil-buprenorphine-diazepam and 5-fluorouracil-paracetamol-nalbuphine-diazepam combinations comparatively showed high mortality. This study also revealed that concurrent administration of some combinations has reduced the overall toxicity, however some combinations showed overall high toxicity then individual therapy, for example methorexate when administered individually revealed high mortality along with marked renal, hepatic and hematological toxicities, while when it is administered concurrently with paracetamol-nalbuphine-diazepam mortality was reduced with overall reduction in different toxicities on the contrary when cyclophosphamide was observed and overall toxicities are also less but when it is administrated with buprenorphine-diazepam mortality greatly increased, with increase in overall toxicities, specifically hepatic and hematological

Present study provides detailed evaluation of adverse effects of cumulative drug administration. Such observations are of undisputed importance but results of this type can only be confirmed after evaluating these combinations clinically, since trial in man is the only valid way of establishing these drug interactions

Download Full Thesis
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S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
120.4 KB
2 1 Introduction 1
248.73 KB
  1.1 Cancer And Pain 1
  1.2 Adverse Drug Reaction 13
  1.3 Evaluation Of Toxicities 22
3 2 Materials And Methods And Results 39
1208.54 KB
  2.1 Section A: Analgesic And Co-Analgesic Drugs 39
  2.2 Section B: Anticancer Drugs 78
  2.3 Section C: Anticancer Drugs In Combination With Analgesic And Co-Analgesic Drugs 101
4 3 Discussion 175
225.92 KB
5 4 Conclusion 205
25.14 KB
6 5 References 208
140.65 KB