Pakistan Research Repository

CUMULATIVE TOXICITIES OF COMMONLY USED ANALGESIC, CO-ANALGESIC AND ANTINEOPLASTIC DRUGS

Khan, Rafeeq Alam (1995) CUMULATIVE TOXICITIES OF COMMONLY USED ANALGESIC, CO-ANALGESIC AND ANTINEOPLASTIC DRUGS. PhD thesis, University of Karachi, Karachi.

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Abstract

A review of the published data about cancer reveals that incidence of cancer is likely to be increased over the next decade, similarly a number of surveys also indicate that cancer and pain always co-exist, this co-existence of pain with cancer necessitate the administration of multiple analgesic drugs with anticancer therapy to patients, which greatly increases the risk of drug toxicities in person already living in miserable conditions, occasionally these risks are predictable on the basis of known pharmacology of the drugs used, but all too often they have emerged only after the exposure of many patients, thus combinations require separate investigation with animal toxicity studies and clinical evaluation in as full a scrutiny as afforded to a completely new drug Considering the prevailing alarming situation of cancer in Pakistan, present study is specifically designed to achieve multifold objectives such as to assess the toxicities of multiple drug administration, not to predict but rather to warn the users and prescribers, of the possible dangers, to discourage the use of combinations which have high cumulative toxicities in animals and to suggest a more useful combination in developing countries like Pakistan where patients have poor performance status and do not give response as can be expected by a particular combination Present study in general has revealed that mortality is high in animals with marked decrease in hemoglobin level and erythrocyte count, therefore out of the nine combinations animal groups which received cyclophossphamide-buprenorphine-diazepam, 5-fluorouracil-buprenorphine-diazepam and 5-fluorouracil-paracetamol-nalbuphine-diazepam combinations comparatively showed high mortality. This study also revealed that concurrent administration of some combinations has reduced the overall toxicity, however some combinations showed overall high toxicity then individual therapy, for example methorexate when administered individually revealed high mortality along with marked renal, hepatic and hematological toxicities, while when it is administered concurrently with paracetamol-nalbuphine-diazepam mortality was reduced with overall reduction in different toxicities on the contrary when cyclophosphamide was observed and overall toxicities are also less but when it is administrated with buprenorphine-diazepam mortality greatly increased, with increase in overall toxicities, specifically hepatic and hematological Present study provides detailed evaluation of adverse effects of cumulative drug administration. Such observations are of undisputed importance but results of this type can only be confirmed after evaluating these combinations clinically, since trial in man is the only valid way of establishing these drug interactions

Item Type:Thesis (PhD)
Uncontrolled Keywords:analgesic drugs, co-analgesic drugs, antineoplastic drugs, cancer, anticancer therapy, cyclophossphamide-buprenorphine-diazepam, 5-fluorouracil-buprenorphine-diazepam, 5-fluorouracil-paracetamol-nalbuphine-diazepam, toxicity, paracetamol-nalbuphine-diazepam, anticancer drugs
Subjects:Biological & Medical Sciences (c) > Medical Sciences (c2) > Pharmacy(c2.5)
ID Code:1390
Deposited By:Mr. Muhammad Asif
Deposited On:19 Feb 2007
Last Modified:04 Oct 2007 21:06

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