I= ISOLATION AND STRUCTURAL STUDIES ON ALKALOIDS OF RHAZYA STRICTA AND SYNTHETIC STUDIES IN THE FILED OF PYRIDYL INDOLES
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Title of Thesis
ISOLATION AND STRUCTURAL STUDIES ON ALKALOIDS OF RHAZYA STRICTA AND SYNTHETIC STUDIES IN THE FILED OF PYRIDYL INDOLES

Author(s)
Sajida Khanum
Institute/University/Department Details
H.E.J. Research Institute of Chemistry/ University of Karachi
Session
1986
Subject
Chemistry
Number of Pages
133
Keywords (Extracted from title, table of contents and abstract of thesis)
rhazya stricta, pyridyl indoles, rhazimine, rhazicine, isorhazicine, strictamine-n-oxide, 2-methoxy-1-2-dihydrorhazimine, rhazisidine, strcitisdine , leuconolam, strictine, bisstrictidine, strictigine, rhazigine, 3- 14-dehydrorhazigine, 16-hydroxyrhazimine, seco ajmalinoid

Abstract
The isolation and structure elucidation of alkaloids of Rhazya stricta have led to the isolation of fourteen new alkaloids. The most interesting of these are those, possessing a novel seco ajmalinoid skeleton. The isolated new alkaloids are named as rhazimine, rhazicine, isorhazicine, strictamine-N-oxide, 2-methoxy-1, 2-dihydrorhazimine, rhazisidine, strcitisdine , leuconolam, strictine, bisstrictidine, strictigine, rhazigine, 3, 14-dehydrorhazigine, 16’-hydroxyrhazimine, Recent spectroscopic techniques were employed to determine their structures, including two dimensional NMR experiments, eg. COSy, NOESY, 2D J-resolved and proton homodecoupling experiments; GASPE and DEPT experiments were carried out determine multiplicity of each carbon atom. Extensive NOE difference studies were carried out to determine relative stereochemistry at various asymmetric centers. Biosynthetic routes to some isolated alkaloids are also proposed.

A part of this thesis comprised studies on the synthesis of pyridyl indoles.

Download Full Thesis
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S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
39.51 KB
2 1 (Part – I )Introduction 1
49.72 KB
3 2 Biosynthesis Of Indole Alkaloids 9
128.43 KB
4 3 Rhazya Stricta 29
17.69 KB
5 4 Results And Discussion 31
343.75 KB
6 5 Experimental 88
134.09 KB
7 6 References 103
61.6 KB
8 7 (Part- II )Synthesis Of Pyridyl Indoles 113
50.6 KB
9 8 Some Model Experiments Towards The Synthesis Rhazya Alkaloids 121
29.55 KB
10 9 Experimental 126
40.44 KB
11 10 References 131
27.2 KB
  10.1 List Of Publications 133