I= STUDIES ON THE STEROIDAL ALKALOIDS OF BUXUS PAPILLOSA AND OTHER RELATED PLANTS
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Title of Thesis
STUDIES ON THE STEROIDAL ALKALOIDS OF BUXUS PAPILLOSA AND OTHER RELATED PLANTS

Author(s)
Zahida Iqbal
Institute/University/Department Details
H.E.J. Research Institute of Chemistry/ University of Karachi
Session
1990
Subject
Chemistry
Number of Pages
230
Keywords (Extracted from title, table of contents and abstract of thesis)
steroidal alkaloids, buxus papillosa, evergreen shrubs, buxus wallichinana, buxus hildebrandtii, buxamine, cycloprotobuxine, cyclomicrobuxine, buxamine, cyclomicrobuxanine, buxoxybenzamine, buxabenzacine, buxapapilinine, cyclovirobuxamine,buxafuranamide

Abstract
The family Buxus comprises 20 species of evergreen shrubs distributed in different parts of the world. Two distinct forms occur in Indo-Pakistan sub-continent, Buxus papillosa C.K. Schneider and Buxus wallichinana. Buxus papillsoa is a large shrub found in northern areas of Pakistan. The early work on this plant was done by G.A Miana and M. Shamma in 1973. Further studies on this plant have been pursued by our group and more than 50 new compounds have been isolated and characterized. Present work is also a continuation of the same and has led to the isolation and identification of five new steroidal bases, two of them bear a novel skeleton. Moreover, three other established bases were also isolated fro the first tome from this plant and their detailed spectral studies were carried out.

In addition, studies on the leaves of Buxus Hildebrandtii were also carried out, which resulted in the isolation and identification of two other known steroidal alkaloids, not detected from this plant previously.

I)Buxafuranamide(107) J. Nat. Prod., in press II)cyclovirobuxamine (108) Phytochemistry, 28(10), 2848,1989 III)Buxapapilinine(109) Heterocycles, 31(3), 493,1990 IV)Buxabenzacine(110) J. Nat. Prod., in press V)Buxoxybenzamine(111) Phytochemistry, 29(2), 683,1990 VI)Cyclomicrobuxanine(112) VII)Buxamine-A(113) VIII)Cyclomicrobuxine(114) IX)Cycloprotobuxine-C(115) X)Buxamine-B(116)

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1413.88 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
82.7 KB
2 1 General Introduction 1
77.7 KB
  1.1 Alkaloids 5
3 2 Steroidal Alkaloids 12
261.98 KB
  2.1 Steroidal Alkaloids From Animal Sources 15
  2.2 Steroidal Alkaloids From Plant Sources 16
  2.3 Classification Of Buxus Alkaloids 24
4 3 Biosynthesis 56
264.18 KB
5 4 Spectral Behavior Of Buxus Alkaloids 73
154.12 KB
  4.1 Uv Spectrophotometery Of Buxus Alkaloids 74
  4.2 Mass Spectroscopy 78
  4.3 Proton Nmr Spectroscopy 82
  4.4 13 c-Nmr Spectroscopy 87
  4.5 Correlation Between Structure And Specific Rotation Of Buxus Alkaloids 91
6 5 Results And Discussion 96
557.38 KB
  5.1 Alkaloids From The Leaves Of Buxus Papillosa 97
7 6 Experimental 174
227.51 KB
  6.1 General Notes 175
  6.2 Alkaloids From The Leaves Of Buxus Papillosa 176
8 7 Alkaloids From Buxus Hildebrandt Ii 205
557.39 KB
  7.1 Introduction 206
9 8 Results And Discussion 206
41.02 KB
  8.1 Cycloprotobuxine- C( 115) 206
  8.2 Buxamine- B( 116) 209
10 9 Experimental 212
24.95 KB
  9.1 Plant Material 212
11 10 References 215
89.82 KB
12 11 List Of Publications 229
12.47 KB