Studies On The Chemical Constituents Of Hedera Nepalensis K. Koch And Cornus Macrophyllawall Ex Roxb

Ashfaq Ahmad, Khan (2014) Studies On The Chemical Constituents Of Hedera Nepalensis K. Koch And Cornus Macrophyllawall Ex Roxb. Doctoral thesis, University Of Peshawar, Peshawar.

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Abstract

research work carried out for the doctoral dissertation is mainly focused on bioassayguided isolation, characterization and structure determination of pure chemical constituents of H. nepalensis K. Koch (Part-A) and C. macrophylla Wall (Part-B). The structures of the pure chemical constituents were elucidated by advanced spectroscopic methods.Part A Chemical explorations of H. nepalensis were described in part A; resulted in the isolation of one new triterpenoid saponin; hepalensiside A (1) and four hitherto unreported triterpenoid saponins colchiside A (2), pastuchoside A (3), helixoside A (4) and kizuta saponin K12 (5) from the leaves of H. nepalensis. Various fractions and extract of H. nepalensis were also evaluated for different bioassays. As a result semi-purified fractions exhibited significant antibacterial activities against P. mirabilis at conc. of 12 ìg/ml, against B. cereus 13 and E. coli 11 ìg/ml, while the methanolic extract of the H. nepalensis was found to be cytotoxic.Part B Part B described the phytochemical studies of C. macrophylla, affording four new chemical constituents; macrophyllanin A (6), macrophyllanin B (7), macrophyllanin C (8) and acrophyllanin D (9), together with three hitherto unreported compounds; kaempferol (10), taraxasterol (11) 3â- hydroxy-18á-olean-28-19â-olide (12) and five known compounds; betulinic acid (13), betulin (14), stigmasterol (15), lupeol (16) and oleanolic acid (17). Semi-purified fractions were also evaluated for biological assays, as a result some fractions were found to be active against B. cereus and Lemna minor (plant) and were also showed cytotoxic effect

Item Type: Thesis (Doctoral)
Uncontrolled Keywords: Macrophyllawall, Studies, Koch, Chemical, Nepalensis, Constituents, Cornus, Hedera
Subjects: Q Science > QD Chemistry
Depositing User: Muhammad Khan Khan
Date Deposited: 20 Sep 2016 04:04
Last Modified: 20 Sep 2016 04:04
URI: http://eprints.hec.gov.pk/id/eprint/1333

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