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STUDIES ON THE CHEMICAL CONSTITUENTS OF PSORALEA PLICATA AND PENTATROPIS SPIRALIS

Rasool, Nazli (1991) STUDIES ON THE CHEMICAL CONSTITUENTS OF PSORALEA PLICATA AND PENTATROPIS SPIRALIS. PhD thesis, University of Karachi, Karachi.

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Abstract

This thesis is divided into two parts. The first part describes the studies on the chemical constituents of Psoralea plicata. In the course of our studies of this plant five new compounds have been isolated and characterized. In addition, six known compounds have also been reported for the first time from this plant New compounds isolated from Psoralea plicata 1. Psoracinol (39) J. Nat. Prod., 52 (4) 749 (1989) 2. Plicatin A (40) Phytochemistry, 29 (12), 2979 (1990) 3. Plicatin B (41) Phytochemistry, 29 (12), 2979 (1990) 4. Plicadin (42) Phytochemistry (in press) 5. α-tocopherolquinone methyl ether (43) Phytochemistry (in press) Known compounds isolated for the first time from Psoralea plicata 1. Squalene (44) 2. α-amyurin (45) 3. β-amyrin (46) 4. Lupeol (47) 5. β-sitosterol (48) 6. Stigmasterol (49) 7. α-tocopherolquinone (50) 8. Methyl-4-hydroxy-cinnamate (51) 9. Acetovanillon (52) The second part of the thesis describes studies on the chemical constituents of Pentatropis spiralis (syn: Asclepias spiralis) which have led to the isolation and characterization of four new terpenoids. In addition, four known triterpenoids have also been reported for the first time from this plant New terpenoids isolated from Pentatropis spiralis 1. cis-Phytyl-plamitate (53) Phytochemistry (in press) 2. Pentatropeline (54) Fitoterapis (submitted) 3. Pentatronol (55) Fitoterapia (submitted) 4. Cyclort-22-ene-3 α, 25-diol (56) J. Nat. Prod., (in press) Known triterpenoids isolated for the first time from Pentatropis spiralis 1. Taraxasterol (57) 2. W-taraxasterol (58) 3. 24-methylenecycloartanol (59) 4. Cycloeucalenol (60) The structures of these compounds were elucidated on the basis of spectral data (Mass, UV, IR, 1H-NMR, COSY-45, J-resolved, NOE, 13C-NMR, DEPT and hetero-COSY) as well as on the chemical studies. The general introduction of this thesis includes a brief account of biogenetic approach to various classes of triterpenoids, phenylpropanoids, phynylcoumarins and quinines. One the other hand, the introductions of part-A and Part-B give comprehensive reviews of earlier research carried out on the chemical constituents of Psoralea and Pentatropis (Asclepias) species

Item Type:Thesis (PhD)
Uncontrolled Keywords:psoralea plicata, pentatropis spiralis, triterpenoids, taraxasterol, w-taraxasterol, cycloeucalenol, cis-phytyl-plamitate, pentatropeline, pentatronol, squalene, lupeol, stigmasterol, α-tocopherolquinone, acetovanillon, β-amyrin , α-amyurin
Subjects:Physical Sciences (f) > Chemistry(f2)
ID Code:1302
Deposited By:Mr. Muhammad Asif
Deposited On:27 Jan 2007
Last Modified:04 Oct 2007 21:05

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