I= STUDIES ON THE EFFECTS AND MECHANISM OF PSYCHOTROPIC DRUGS
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Title of Thesis
STUDIES ON THE EFFECTS AND MECHANISM OF PSYCHOTROPIC DRUGS

Author(s)
Shahida Perven Ahmed
Institute/University/Department Details
University of Karachi/ Department of Pharmacology
Session
1994
Subject
Pharmacy
Number of Pages
223
Keywords (Extracted from title, table of contents and abstract of thesis)
psychotropic drugs, phenyl propanoids, cinnamic acid, coumaric acid, pentobarbitone, amphetamine

Abstract
No Abstract.

Download Full Thesis
1762.54 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents 0
99.87 KB
2 1 Introduction 1
200.62 KB
  1.1 General 3
  1.2 Psychotropic drugs 8
  1.3 Ethnopharmacological survey of plants 15
  1.4 Phenyl propanoids ( PhGs ) 18
  1.5 Pharmacological effect of cinnamic and coumaric acid derivatives 22
  1.6 Aims and objectives 26
3 2 Materials and methods 28
174.3 KB
  2.1 General methods of neuropharmacological screening for test drugs (plant crude extracts, natural products of plant origin and pure commercial compounds ) 28
  2.2 Plant crude extracts (crude drugs ) 28
  2.3 Natural products 34
  2.4 Fure commercial compounds 34
  2.5 Behavioural study 34
  2.6 Motor activity 37
  2.7 Traction test 37
  2.8 Inclined screen test 37
  2.9 Chimney test 38
  2.10 Hypogenic activity 38
  2.11 Potentiation of pentobarbitone sleeping time 38
  2.12 Antiaggressive behaviour 38
  2.13 Scoring scale for amphetamine-induced behaviour 39
  2.14 Measurement of catalepsy following administration of test materials (crude extracts or compounds ) 40
  2.15 Analgesic activity 41
  2.16 Anticonvulsant activity 41
  2.17 Exploratory behaviour pattern 42
  2.18 In vivo experiments (for natural products and pure commercial compounds 43
  2.19 In vivo experiments (for natural products and pure commercial compounds 47
  2.20 Antibacterial activity (for natural products and pure commercial compounds ) 48
  2.21 Haemolytic plaque assay (for natural products and pure commercial compounds ) 50
4 3 Results and discussion 53
1524.3 KB
  3.1 Effect on motor activity 53
  3.2 Effect on traction test performance 53
  3.3 Inclined screen test 62
  3.4 Effect of crude drugs on natural products and pure commercial compounds on pentobarbitone -induced hypnosis and righting reflex ( hypogenic activity ) 62
  3.5 Antiaggressive behaviour 62
  3.6 Amphetamine-induced behaviour 71
  3.7 Effect of natural products and pure commercial compounds on catalepsy 84
  3.8 Analgesic activity 84
  3.9 Effect on the time of onset of clonic and tonic convulsions 93
  3.10 Efect on exploratory behaviour 93
  3.11 Effect of natural products and commercial compounds on hypertension 113
  3.12 Effect of natural products and pure commercial compounds on biogenic amines 126
  3.13 Antimicrobial activity of natural products and pure commercial compounds 146
  3.14 Effect of natural products and pure commercial compounds on platelet aggregation 156
  3.15 Effect of natural products and pure commercial compounds on isolated tissue (skeletal muscle ) 160
  3.16 Detection of antibody producing cells by haemolytic plaque assay 161
5 4 General discussion 170
118.81 KB
6 5 Summary 185
17.51 KB
7 6 Acknowledgements 186
12.89 KB
8 7 References 188
266.74 KB