I= ISOLATION AND STRUCTURAL STUDIES ON COCCULUS PENDULUS
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Title of Thesis
ISOLATION AND STRUCTURAL STUDIES ON COCCULUS PENDULUS

Author(s)
Kishwar Jahan
Institute/University/Department Details
H.E.J. Research Institute of Chemistry/ University of Karachi
Session
1998
Subject
Number of Pages
144
Keywords (Extracted from title, table of contents and abstract of thesis)
cocculus pendulus, crude alkaloids, bisbenzylisoquinolines, benzylisoquinolines

Abstract
The thesis describes the isolation and structure elucidation of the following eleven new alkaloids from the leaves of C. pendulus:

Siddiquine (1), siddiquamine (2), 12-O-methyldehydrokohatine (3), dehydrokohatine (4), 1,2-dehydro-2’-nortelobine (5), 5’-hydroxyapateline (6), 12-O-methylkohatine (7), 5-hydroxytelobine (8),1,2-dehydrokohatine-2-β-N-oxide (9), cocsupendine (10), o,o-dimethy1-1,2-dehydrokohatine-norkohtine (11).

Careful spectroscopic studies have been carried out to solve the structures of all the new alkaloids (U.V., I.R., mass, 1H-NMR, 13C-NMR and Noeds).

In addition to these all aloids, we have isolated 1,2-dehydrotelobine (12), which was previously not reported from C. pendulus, along with the known alkaloids kohatine (13) and cocsoline (14)°

Download Full Thesis
854.89 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
35.08 KB
2 1 The Bisbenzylisoquinoline Alkaloids 1
236.83 KB
  1.1 Introduction 1
  1.2 Biosynthesis 10
  1.3 Oxidation Using Catechol Dioxygenases 14
  1.4 Unusual Alkaloids and Their Biogenesis 18
  1.5 Biosynthesis of Benzylisoquinolines 22
  1.6 Biosynthesis of Bisbenzylisoquinolines 30
3 2 Isolation and Structural Studies on Alkaloids of Cocculus Pendulus 36
124.06 KB
  2.1 Introduction 36-37
4 3 Results and Discussion 55
424.59 KB
  3.1 Extraction Procedure 55-56
5 4 Experimental 119
153.87 KB
  4.1 General Notes 119
  4.2 Extraction of Crude Alkaloids of Cocculus Pendulus 119-120
6 5 References 139-144
47.42 KB
7 6 List of Publications 144
11.98 KB