ISOLATION AND STRUCTURAL STUDIES ON COCCULUS PENDULUS

Abstract

The thesis describes the isolation and structure elucidation of the following eleven new alkaloids from the leaves of C. pendulus: Siddiquine (1), siddiquamine (2), 12-O-methyldehydrokohatine (3), dehydrokohatine (4), 1,2-dehydro-2’-nortelobine (5), 5’-hydroxyapateline (6), 12-O-methylkohatine (7), 5-hydroxytelobine (8),1,2-dehydrokohatine-2-β-N-oxide (9), cocsupendine (10), o,o-dimethy1-1,2-dehydrokohatine-norkohtine (11). Careful spectroscopic studies have been carried out to solve the structures of all the new alkaloids (U.V., I.R., mass, 1H-NMR, 13C-NMR and Noeds). In addition to these all aloids, we have isolated 1,2-dehydrotelobine (12), which was previously not reported from C. pendulus, along with the known alkaloids kohatine (13) and cocsoline (14)°