I= PHYTOCHEMICAL INVESTIGATIONS ON AJUGA PARVIFLORA AND PAEONIA EMODI
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Title of Thesis
PHYTOCHEMICAL INVESTIGATIONS ON AJUGA PARVIFLORA AND PAEONIA EMODI

Author(s)
Pir Muhammad
Institute/University/Department Details
University of Karachi/ H.E.J Research Institute of Chemistry
Session
1999
Subject
Chemistry
Number of Pages
201
Keywords (Extracted from title, table of contents and abstract of thesis)
ajuga parviflora, paeonia emodi, a. parviflora, withanolides

Abstract
This dissertation describes the phytochemical investigation on the two medicinally important plants of Pakistan namely Ajuga parviflora and paeonia emodi

Phytochemical studies on the whole plant of A. parviflora have led to the isolation of fourteen compounds. Among these compounds eight are new while the remaining six are new source compounds. The new compounds are, 4-acetyloxy-4-(methylenecarboethoxy)-cyclohexa-2, 5-dienone (51), 4-acetyloxy-4-(methylenecarboethoxy)-cyclohexa-2, 5-dienone (52), 4-hydroxy-4-(methylenecarboethoxy)-cyclohexa-2, 5-dienone (53), Ajugin A (60), Ajugin B (61), Ajugin C (62) and Ajugin D (63). The new source source compounds are, 4-hydroxy-4-(methylenecarboethoxy)-cyclohexa-2, 5-dienone (54), β-sitosterol (55), stigmast-erol (56), lupeol (57) oleanolic acid (58) and ajugalactone (64) Fitoterapia 1999 70, 229. Fitoterapia 1999, 70, 229. Fitoterapia 1999 70, 229.Phytochemistry 1999, 51, 669. J. Nat. Prod. 1999, 62, 1290. J. Nat. Prod. 1999, 62, 1920. Helv. Chim. Act. 1999, 82, 1423. Helv. Chim.. Act. 1999, 82, 1423

Studies on the chemical constituents of Paeonia emodi resulted eight compounds. Among these compounds two monoterpene glyxosides Wurdin (65) and Benzoyl wurdin (66) are new, the Lactiflorin (67), Galloyoxypaeoniflorin (68), 1,5-dihydroxy-3-methylanthraquinone (69) Methyl grevillate (70), Ethyl gallate (71) are new source compounds while Paeoniflorin (72) is know compkound

The structures of these know and known natural products were determined on the basis of extensive spectroscopy including one-and two- and inverse two-dimensional NMR experiments (like COSY and HMQC) and chemical derivatizations Z.fut Naturforschung 1999, 54b, 544, Z. Fur Naturforschung 1999, 54b, 544.

Download Full Thesis
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S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents 0
89.55 KB
2 1 Ajuga Parviflota 1
1170.61 KB
  1.1 Pharmacological Importance Of Genus Ajuga 9
  1.2 Introduction To Withanolides 11
  1.3 Phytochemical Studies On Ajuga Parviflora 45
  1.4 New Withanolides From Ajuga Parviflora 71
  1.5 Experimental 118
  1.6 Determination Of Antimicrobial Activity 119
  1.7 Plant Material 120
3 2 Paeonia Emodi 142
368.1 KB
  2.1 New Compounds From Paeonia Emodi 148
  2.2 Phytochemical Study On Paeonia Emodi 147
  2.3 Unreported Compounds From Paeonia Emodi 162
  2.4 Reported Compound From Paeonia Emodi 172
  2.5 Experimental 174
  2.6 Plant Material 174
4 3 References 187
119.28 KB
5 4 List Of Publications 199
25.98 KB
6 5 Publications Resulted From This Work 201
13.77 KB