Pakistan Research Repository

ISOLATION AND STRUCTURAL STUDIES ON CHEMICAL CONSTITUENTS OF TINOSPORA MALABARICA AND NIGELLA SATIVA

Ahmed, Sultan (1990) ISOLATION AND STRUCTURAL STUDIES ON CHEMICAL CONSTITUENTS OF TINOSPORA MALABARICA AND NIGELLA SATIVA. PhD thesis, University of Karachi, Karachi.

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Abstract

This thesis presents investigation no two medicinal plants of Pakistan: Tinospora Malabarica and Nigella sativa. Studies on the chemical constituents of the fresh stems of Tinospora malabarica have led to the isolation of four new furanoid diterpenoids: tinosporicide, 10α-hydroxy-columbin, malabarolide and malabarolonide. In addition, three known compounds have also been detected for the first time in this plant. Modern spectroscopic methods were employed to determine their structures including two-dimensional NMR experiments e.g. 2D J-resolved, COSY-45, L.R. COSY, NOESY, Hetero-COSY, L.R. Hetero-COSY. GASPE as well as DEPT experiments were carried out to determine the multiplicity of each carbon atom. Two of these furanoid diterpenoids were of novel skeleton which were confirmed by X-ray diffraction analysis. Biosynthetic routes of these diterpenoids are also proposed Investigation on the chemical constituents of the seeds of Nigella sativa resulted in the isolation of a alkaloid: nigellimine N-oxide. Its structure has also been established by modern spectroscopic techniques. Biosynthetic route to this alkaloid is proposed

Item Type:Thesis (PhD)
Uncontrolled Keywords:tinospora malabarica, nigella sativa, furanoid diterpenoids, tinosporicide, 10α-hydroxy-columbin, malabarolide, malabarolonide, isoquinoline alkaloids, tinospora malabarica, terpenes, terpenoids
Subjects:Physical Sciences (f) > Chemistry(f2)
ID Code:1191
Deposited By:Mr. Muhammad Asif
Deposited On:03 Jan 2007
Last Modified:04 Oct 2007 21:05

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