I= PHYTOCHEMICAL INVESTIGATION ON THE CHEMICAL CONSTITUENTS OF PAEONIA EMODI WALL, ALYSICARPUS MONOLIFER LINN. AND AJUDA BRACTEOSA WALL
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Title of Thesis
PHYTOCHEMICAL INVESTIGATION ON THE CHEMICAL CONSTITUENTS OF PAEONIA EMODI WALL, ALYSICARPUS MONOLIFER LINN. AND AJUDA BRACTEOSA WALL

Author(s)
Naheed Riaz
Institute/University/Department Details
H.E.J. Research Institute of Chemistry/ University of Karachi
Session
2004
Subject
Chemistry
Number of Pages
237
Keywords (Extracted from title, table of contents and abstract of thesis)
paeonia emodi wall, alysicarpus monolifer linn., ajuda bracteosa wall, alysional, triterpenoid, oleane, labiatae, withanolides, papilionaceae, genus alysicarpus

Abstract
God has gifted Pakistan with enormous varieties of medicinal plants. Out of these only 20% have so far been evaluated for their therapeutic potentials. Therefore, there is a need of coordinated and well-organized efforts in the area of chemistry of indigenous medicinal plants. The H.E.J. Research Institute of Chemistry is one of the most sophisticated and advanced centre of the world fro plant chemistry. It was initially established by well-known senior scientist of Pakistan late Prof. Salimuzzaman Siddiqui. After him the institute has been ably served by reknowned Pakistani Scientist Prof. Atta-ur-Rahman. The institute has state of art facilities for bioassay directed studies on medicinal plants. The present Ph. D. thesis deals with the pharmacochemical studies on three indigenous medicinal plants of Pakistan namely Paeonia emodi, Alysicarpus monolifer and Ajuga bracteosa. The thesis is, therefore presented in the following three parts:

Part-A : Phytochemical Investigations on the Chemical constituents of paeonia emodi wall. Paeonia emodi wall. (Paeonianceae) occurs in the northern areas of Pakistan at high altitude. Various Paeonia species including Paeonia emodi wall. are used as anticoagulant, emmenaguge, anticoagulant and in the treatment of scarlet fever, haemorrhage, bilious obstructions, dropsy, epilepsy and hysteria [1-4] Phytochemical studies on the ethanolic extracts of roots and fruits of P. emodi, elucidation of five new and thirteen known compounds.

Part-B:Phytochemical investigations on the Chemical constituents of Alysicarpus monolifer Linn. Alysicarpus monolifer Linn. Belongs to the family Papilionacease. The plant has been sued in indigenous system of medicine for the treatment of leprosy, cough, purgative, anti-pyretic, stomach pain and expectorant properties [3,4]. Phytochemical studies on the whole plant material, collected from Karachi (Pakistan), have resulted in the isolation and structure elucidation of a new triterpenoid of oleane series named as alysional. In addition five known compounds have also been isolated for the first time from this species.

Part-C:Phytochemical investigations on the Chemical constituents of Ajuga bracteosa wall.Ajuga bracteosa wall. belongs to the family Labiatae and has found diverse medicinal uses in the indigenous systems, of medicine. It has been used as bladder[1-3]. The systematic phytochemical studies on the whole plant material, collected from Swat (Pakistan), have led to the isolation and structure elucidation of three new withanolides. Beside, a number of unreported compounds have been isolated characterized
Download Full Thesis
1817.58 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
170.64 KB
2 1 Paeonia Emodi 1
239.32 KB
  1.1 Paeoniaceae 3
  1.2 Literature Survey On Paeonia Species 4
  1.3 Terpenoids 9
  1.4 Biosynthesis Of Mono And Triterpenoids 11
  1.5 Alternate Deoxxylulose Phosphate Pathway 27
3 2 Results And Discussion 28
428.85 KB
  2.1 New Compounds From Paeonia Emodi 31
  2.2 Structure Elucidation Of Known Compounds 65
4 3 Experimental 80
302.68 KB
  3.1 General Experimental Conditions 81
  3.2 Plant Material 82
  3.3 Extraction And Isolation 82
  3.4 Literature Cited 109
5 4 Alysicarpus Monolifer 116
29.06 KB
  4.1 Papilionaceae 118
  4.2 Literature Survey On Genus Alysicarpus 119
6 5 Results And Discussion 120
115.96 KB
  5.1 Structure Elucidation Of New Compound 122
  5.2 Structure Elucidation Of Known Compounds 128
7 6 Experimental 135
86.76 KB
  6.1 Plant Material 136
  6.2 Extraction And Isolation 137
  6.3 Literature Cited 145
8 7 Ajuga Bracteosa 147
267.43 KB
  7.1 Labiatae 149
  7.2 Introduction Survey On Ajuga Species 150
9 8 Results And Discussion 177
292.49 KB
  8.1 New Compounds From Ajuga Bracteosa 179
  8.2 Structure Elucidation Of Known Compounds 203
10 9 Experimental 215
185.24 KB
  9.1 Plant Material 216
  9.2 Extraction And Isolation 218
  9.3 Literature Cited 228
  9.4 List Of Publications 236