I= STUDIES IN THE CHEMICAL CONSTITUENTS OF ERIGERON CANADENSIS (CONYZA CANANDSIS) AND BERCHEMIA PAKISTANICA
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Title of Thesis
STUDIES IN THE CHEMICAL CONSTITUENTS OF ERIGERON CANADENSIS (CONYZA CANANDSIS) AND BERCHEMIA PAKISTANICA

Author(s)
Naveen Mukhtar
Institute/University/Department Details
H.E.J Research Institute of Chemistry/ University of Karachi
Session
2004
Subject
Chemistry
Number of Pages
245
Keywords (Extracted from title, table of contents and abstract of thesis)
erigeron canadensis, conyza canandsis, berchemia pakistanica, sphingolipids, genus conyza, genus berchemia

Abstract
The art of healing has its origin in the antiquity of human civilization. Even in prehistoric times, the man was fully able to distinguish those plants, which had healing properties from those having toxicities. Great reservoirs of knowledge on medicinal plants have been provided by Chinese, Sumerian, Babilonian, Egyptian, Greek, and Muslim civilizations. In the indo-Pakistan subcontinent records of the indigenous system of medicine known as Ayurveda, go back to 700 B.C., and its systematization is attributed to charaka and susruta, who have cited about seven hundred medicinal plants.

In Indo-Pakistan subcontinent, there has been a fairly organized effort for pharmacological studies in the physiologically active plant constituents. Various centers have been established in both India and Pakistan for systematic studies on medicinal plants. The most recent and sophisticated amongst these is H.E.J research Institute of Chemistry, University of Karachi, where bioassay directed isolation studies of active plant constituents are routinely carried out. These studies have already resulted in hundred of new natural products possessing promising potentials for the treatment of serious human ailments like aids, cancer tumor, diabetes, hypertension, etc.

The present thesis describes the bioassay directed isolation studies of bioactive natural products from two medicinal plants namely Erigeron Canadensis (syn. Conyza Canadensis) and Berchemia Pakistanica. Both of these occur in southern part of Pakistan and are used by local physicians for the treatment of a variety of ailments. The thesis is , therefore, presented in two parts namely.

Part-A Studies in the chemical constituents of erigeron Canadensis (syn. Conyza linn)

Part-B Studies in the chemical constituents of berchemia Pakistanica browicz

“Studies in the chemical constituents of erigeron Canadensis (syn. Conyza Canadensis linn.)”

Phytochemical studies on the methanolic extract of the whole plant materials have resulted in the isolation and structural elucidation of five new sphingolipids along with nine other compounds reported for the first time from this species.

Download Full Thesis
2008.35 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
180.01 KB
2 1 Introduction (Part-A) 2
493.17 KB
  1.1 General introduction of the genus conyza 3
  1.2 Sphingolipids 30
  1.3 Biosynthesis of sphingolipids 39
  1.4 Biological activity of sphingolipids 49
  1.5 Functions of sphingolipids 53
  1.6 Applications of sphingolipids 54
3 2 Results and discussion 57
424.59 KB
  2.1 Pharmacological screening of conyza Canadensis 58
  2.2 Phytochemical studies on conyza Canadensis 59
4 3 Experimental 108
228.93 KB
  3.1 General experimental conditions 109
  3.2 Plant material 110
  3.3 Extraction, fractionation and isolation 111
  3.4 Determination of biological activities 132
  3.5 Enzyme- inhibition assay 133
5 4 References 135
117.09 KB
6 5 Introduction (Part-B) 147
181.08 KB
  5.1 General introduction of the genus berchemia 148
  5.2 Biosynthesis 157
7 6 Results and discussion 169
412.17 KB
  6.1 Pharmacological screening of berchemia Pakistanica 170
  6.2 Phytochemical studies on berchemia Pakistanica 172
8 7 Experimental 215
200.84 KB
  7.2 Plant material 216
  7.3 Extraction, fractionation and isolation 216
  7.4 Determination of biological activities 235
  7.5 Enzyme-inhibition assays 236
9 8 References 239
62.62 KB
10 9 Research articles 245
14.89 KB