I= BIOACTIVE CHEMICAL CONSTITUENTS OF SYMPLOCOS FACEMOSA AND COMIPHORA MUKUL
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Title of Thesis
BIOACTIVE CHEMICAL CONSTITUENTS OF SYMPLOCOS FACEMOSA AND COMIPHORA MUKUL

Author(s)
Muhammad Athar Abbasi
Institute/University/Department Details
H.E.J. Research Institute of Chemistry/ University of Karachi
Session
2004
Subject
Chemistry
Number of Pages
139
Keywords (Extracted from title, table of contents and abstract of thesis)
symplocos facemosa, comiphora mukul, medicinal plant, symplocos racemosa, genus symplocos, gentisyl alcohol, burseraceae, genus commiphora

Abstract
The work embodied in this dissertation is mainly concerned with the isolation and characterization of chemical constituents from two terrestrial medicinal plants and their possible biological activities. The isolated compounds whether new or have been previously reported in the literature, were characterized by using various sophisticated spectroscopic techniques available at this institution. This dissertation is split in two parts, A and B.

Part A BIOACTIVE CHEMICAL CONSTITUENTS OF SYMPLOCOS RACEMOSA

The phytochemical investigation of Symplocos racemosa Roxb. resulted in the isolation of eight new chemical constituents, out of these, five are phenolic glycosides of salirepin series, two are C-glycosides while one is a naturally ethyl substituted glycoside. The new compounds include benzoylsalireposide (49), symploracemoside (50), symplomoside (51), I-O-ethyl brachiose-3'-acetate (52), symploveroside (53), symplososide (54), symonoside (55) and symplocomoside (56). Except compound 52, all these chemical constituents displayed inhibitory potential against snake venom phosphodiesterase I. In addition to this enzyme, 49, 54, 55, and 56 also possessed inhibitory activity against thymidine phosphorylase. Against lipoxygenase 49, 52, and 56 showed inhibition but other constituents could not be screened due to insufficient quantities, while compound 56 was also found to be a urease inhibitor. The structures of new chemical constituents are shown below:

Part B BIOACTIVE CHEMICAL CONSTITUENTS OF COMMIPHORA MUKUL

The phytochemical studies on the Commiphora mukul Engl. led to the isolation of two lignans, epiexcelsin (21) and 5'-demetaoxyepiexcelsin (22), which belong to the fused bistetrahydrofuran series and are reported for the first time from this species. These lignans displayed inhibitory potential against a-glucosidase and chymotrypsin enzymes.

Download Full Thesis
1644.56 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
178.49 KB
2 1 Introduction (Part-A) 1
106.97 KB
  1.1 Symplocaeae 1
  1.2 The Genus Symplocos 1
  1.3 The Species Symplocos Racemosa 2
  1.4 Phytochemical : Their Role In The Modern Times 4
  1.5 Naturally Occurring Glycosides 8
  1.6 Diversity And Importance Of Plant Phenolics 10
3 2 Literature Review 11
42.85 KB
  2.1 Chemical Constituents Of The Genus Symplocos 11
4 3 Biosynthesis 14
54.35 KB
  3.1 Biosynthesis Of Aromatic Rings 14
  3.2 Shikimate Pathway 14
  3.3 Biosynthesis Of Gentisyl Alcohol 16
  3.4 Biosynthesis Of Benzoic Acid Derivatives 18
5 4 Results And Discussion 20
724.24 KB
  4.1 Present Work 20
  4.2 Structure Elucidation Of Chemical Constituents Of Symplocos Racemosa 204
  4.3 Bioactivity Of The Chemical Constituents Of Symplocos Racemosa 63
6 5 Experimental 71
305.9 KB
  5.1 General 71
  5.2 Spray Reagents 71
  5.3 Symplocos Racemosa 72
  5.4 Characterization Of The Chemical Constituents Of Symplocos Racemosa 76
  5.5 In Vitro Enzyme Inhibition Assay 97
7 6 Introduction (Part-B) 104
62.85 KB
  6.1 Burseraceae 104
  6.2 The Genus Commiphora 104
  6.3 The Species Commiphora Mukul 104
  6.4 Chemical Constituents Of Commiphora Mukul 105
8 7 Results And Discussion 109
227.03 KB
  7.1 Present Work 109
  7.2 New-Source Chemical Constituents Of Commiphora Mukul 109
  7.3 Known Chemical Constituents Of Commiphora Mukul 118
9 8 Experimental 125
101.58 KB
  8.1 General 125
  8.2 Spray Reagents 125
  8.3 Commiphora Mukul 126
  8.4 Characterization Of The Chemical Constituents Of Commiphora Mukul 128
  8.5 In Vitro Enzyme Inhibition Assay 135
10 9 References 136
41.71 KB
  9.1 Research Publications 138