Pakistan Research Repository

ENDOGENOUS INHIBITORS OF LIPID PEROXIDATION, PLATELET AGGREGATION AND ARACHIDOING ACID METABOLISM IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Muhammad, Shafiq (1995) ENDOGENOUS INHIBITORS OF LIPID PEROXIDATION, PLATELET AGGREGATION AND ARACHIDOING ACID METABOLISM IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE. PhD thesis, University of Karachi, Karachi.

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Abstract

Arachidonic acid (All.) plays a unique role in a biological system for the regulation of various cell functions since it can not only be metabolised to potent vasoactive products, collectively known as eicosanoids, but can undergo the process or lipid peroxidation (LP). The resultant products have been implicated in the aetiology or various features associated with chronic obstructive pulmonary disease (COPD). In addition, some of them are capable of influencing platelet aggregation. Although much is known about the role of these mediators, their control mechanisms are imperfectly understood. Their ill vivo generation is thought to be regulated, at least in part. by the plasma endogenous factors that inhibit the processes of AA metabolism, LP and platelet aggregation respectively. The activity of these inhibitors has not been evaluated in COPD. Thus, the present study was undertaken to ascertain the same by investigating the aggregation and All. metabolism of healthy platelets and LP activity in the presence of plasma obtained from patients suffering from either type of COPD (bronchial asthma. chronic bronchitis, emphysema and bronchiectasis). A total of 109 patients were studied and compared with 30 control healthy subjects. The data showed that activity of endogenous inhibitors "I' platelet aggregation, All. metabolism and LP decreased significantly in almost all the groups or patients as compared to control subjects. Results have also indicated the presence of stimulator)' substance(s) for prostaglandin synthesis in the plasma of these patients. This is suggestive of the fact that these processes are enhanced in COPD. Which, in turn, may lead to over-production of several vasoactive products including prostaglandins. thromboxanes, leukotrienes and LP products such as aldehydes. These mediators have been suggested to play a significant role in the underlying mechanisms of the features that contribute in the development of COPD. Thus, it may be suggested that efforts/ studies be directed to explore the exact nature and kinetics of these inhibitors/stimulants An improved understanding of these regulating factors will help us to develop specific synthetic inhibitors and anti-stimulants, so as to keep the in vivo generation of the aforementioned mediators within useful range. This may provide us with new strategies and modalities in the treatment of chronic obstructive pulmonary disease.

Item Type:Thesis (PhD)
Uncontrolled Keywords:chronic obstructive pulmonary disease, lipid peroxidation, platelet aggregation, arachidoing acid, prostaglandins. thromboxanes, leukotrienes, aldehydes
Subjects:Biological & Medical Sciences (c) > Medical Sciences (c2)
ID Code:1154
Deposited By:Mr. Muhammad Asif
Deposited On:30 Dec 2006
Last Modified:04 Oct 2007 21:04

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