Nasim, Shama (2003) PHYTOCHEMICAL STUDIES ON IRIS SPECIES AND SYNTHESIS OF DIFFERENT HETEROCYCLIC COMPOUNDS. PhD thesis, University of Karachi, Karachi.
The work embodied in this Ph.D dissertation is presented in three parts: first, phytochemical investigation on the rhizomes of iris germanica (Part A) and iris soforana (Part B), two medicinally important plant of Turkish origin, second, synthesis and structure activity relationship(SAR) of the naturally occurring embelin and its derivatives on prolyl endopeptidase (part C-I); and third anit-inflammatory (Part-II), and ÃÂÃÂÃÂÃÂ±-glycosidase (Part C-III) activities of compounds isolated from the above-mentioned plants. Part-A this part of the thesis deals with the phytochemical investigation of the rhizomes of iris germanica. The introduction includes a brief review of earlier research work on the chemical constituents and pharmacological activity of the plant. The present study has led t the isolation of seven new isoflavonoids glycosides 56-62 and one synthetically known compounds 63 along with twelve known compounds 64-75 Part-B This part present results of studies on the rhizomes of another Turkish medicinal plant iris soforana that yielded two new isoflavonoids 76-77 along with eleven known compounds 78-88 including ÃÂÃÂÃÂÃÂ²-sitosterol, stigmasterol, a benzene derivative and several other simple isoflavones. According t the best of our knowledge, no phytochemical works has been conducted previously on this plant and this is the first report of the phytochemical investigation of Iris soforana. Part-C results compiled in part C are divided into three sections (parts, I, II and III), largely describing the results of some biological assays on the synthetic derivatives, known and new compounds. Some of these compounds were found to be active against the enzymes PEP and ÃÂÃÂÃÂÃÂ±-glucosidase, as well as active in anit-inflammatory assay.
|Item Type:||Thesis (PhD)|
|Uncontrolled Keywords:||iris species, heterocyclic compounds, family irideaceae, genus iris, iris germanica l, iris soforana l., isoflavonoids, iris germanica, embelin, prolyl endopeptidase|
|Subjects:||Physical Sciences (f) > Chemistry(f2)|
|Deposited By:||Mr. Muhammad Asif|
|Deposited On:||03 Jan 2007|
|Last Modified:||04 Oct 2007 21:04|
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