I= HAEMATOLOGICAL STUDIES DURING CONGENITAL AND ACQUIRED MALARIA OF HUMAN IN KARACHI WEST
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Title of Thesis
HAEMATOLOGICAL STUDIES DURING CONGENITAL AND ACQUIRED MALARIA OF HUMAN IN KARACHI WEST

Author(s)
Tabassum Zafar
Institute/University/Department Details
Department of Zoology/ University of Karachi
Session
1997
Subject
Zoology
Number of Pages
233
Keywords (Extracted from title, table of contents and abstract of thesis)
congenital malaria, acquired malaria, p. falciparum (kfs), p. vivax (kvs), malariacides, malaria parasites

Abstract
The reports of congenital malaria in Karachi region have recently increased due to the P. falciparum (KFs) and P. vivax (KVs) are the most prevalent species in Karachi. In the same area a point of prevalence survey yielded parasite rates of 4.45 per cent. in congenital cases and 14 per cent. in acquired malaria cases (infants). Reliable data on the incidence of congenital malaria are provide as the efficiency of diagnosis and notification has shown a serious deterioration. Since the beginning of the 1990,s congenital malaria has been reported for P. falciparum, P. vivax, P. malariae and P. ovale (Jenkins, 1957; Dhatt, 1979 and Haider, 1992), but on world wide basis this is the first instance in which two virulent malaria strains (KFs and KVs) were detected concurrently in the congenital cases. Although the hematology of man has been well documented, a few studies have been reported on the hematology of man during malaria. The published reports on the hematological reactions to antimalarial drugs and congenital malaria infections are very scanty and insufficient.

The present studies have pointed out, the hematological responses following the administration of malariacides have occurred at such a short interval after the initial administration of the drugs as to eliminate the possibility of a causal relationship. Exhaustive reviews concerning the various aspects of chemotherapy of malaria have been published recently (Hall, 1975; MiIler,1980; Lampe, 1986; Kennelly, 1990 and Haider, 1996). The erythrocytic cycle of malaria parasites are sensitive to several groups of chemical compound.

If the drug is administered early in the infection before heavy damage occurs, recovery usually results. Therefore, present author compared. sequential (for the studies of chemoprophylactic activity of chloroquine phosphate plus oxytetracycline and Fansidar against P. falciparu111 Karachi strain (KFs) and P. vivax Karachi strain (KVs) in test animals) treatment with above mentioned malariacides in the induced parasitized . selected groups of splenectomized and non-splenectomized test animals, which included some who were severely ill or had complications.

The details are given in results section.

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S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
42.85 KB
2 1 Introduction 1
54.87 KB
3 2 Present Studies 8
19.13 KB
4 3 Objectives 10
18.11 KB
5 4 Review Of Literature 12
1103.6 KB
  4.1 Parasitological Findings 78-79
  4.2 Hematological Findings 88-96
  4.3 Clinical Pharmacological Findings 105-117
  4.1 Tables 123-148
6 5 Summary 151
28.92 KB
  5.1 Summary Urdu 153
7 6 Conclusions 154
727.95 KB
  6.1 Acknowledgements 159
  6.2 Plates(1-13) 161
  6.3 References 186