I= BIOPROSPECTING STUDIES ON SARCOCOCCA HOOKERIANA BAIL., SONCHUS WIGHTIANUS DC, PARIS POLYPHYLLA SMITH AND RELATED MEDICAL PLANTS OF NEPAL
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Title of Thesis
BIOPROSPECTING STUDIES ON SARCOCOCCA HOOKERIANA BAIL., SONCHUS WIGHTIANUS DC, PARIS POLYPHYLLA SMITH AND RELATED MEDICAL PLANTS OF NEPAL

Author(s)
Krishna Prasad Devkota
Institute/University/Department Details
H.E.J. Research Institute of Chemistry/ University of Karachi
Session
2005
Subject
Chemistry
Number of Pages
223
Keywords (Extracted from title, table of contents and abstract of thesis)
sarcococca hookeriana bail., sonchus wightianus dc, paris polyphylla smith, medical plants, nepal, bioprospecting studies, steroidal alkaloids, terminaline (10), chonemorphine (11), n-methylpachysamine-a(12), dictyophelbine(13), salignamide-a(14), sarcovagine-d(16), na-methylepipachysamine-d(17), przewalskinone b (23), polyphyllin-c(24), polyphyllin-d(25), saponin-1 (26), stigmasterol(27) glucoside(28), cycloeuphhordenol(29), 1-cyclohexy1-11-heneicosanone(30), β-amyrin (18), β-amyrin acetate(19), β-amyrinone(20), β-sitosterol (21), β-sitosterol glucoside(22), tinospora cordifolia, paris polyphlla

Abstract
This Ph. D. dissertation is divided into four parts, focusing on the bioprospecting studies on four medicinally important plants of Nepalese origin.

Part B of the thesis contains the b oprospectig studies on sonchus wightinaus DC. That resulted in the isolation of five known secondary metabolites. The isolation was carried out by following the results of acetyl-cholinesterase inhibition assays and phytotoxicity assay on Lemna minor. Most of the fractions were found to be active in the bioassay screenings. The known compounds were identified as β-amyrin (18), β-amyrin acetate(19), β-amyrinone(20), β-sitosterol (21), and β-sitosterol glucoside(22).

Part C describes the bioprospecting study on paris polyphylla smith. During this study, six known compounds przewalskinone B (23), polyphyllin-C(24), polyphyllin-D(25), saponin-1 (26), stigmasterol(27) glucoside(28) were obtained. The tyrosinase inhibitory, antilieshmanial and cytotoxicity (on human neutrophils) assays were carried out on these compounds.

Part D. This part includes the results of phytochemical study on a medicinal plant, tinospora cordifolia miers., which afforded three known compounds, cycloeuphhordenol(29), 1-cyclohexy1-11-heneicosanone(30). Most of the fractions of the plant extract as well as compound 31 showed potent to moderate antioxidant activities.

Download Full Thesis
124524.91 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
6259.25 KB
2 1 General Introduction 1
1924.24 KB
3 2 Part A( Bioprospecting Studies On Sarcococca Hookeriana ) 4
82878.03 KB
  2.1 Introduction 5
  2.2 Results And Discussion 40
  2.3 Experimental 117
  2.4 Biological Activities On Steroidal Alkaloids And Their Derivatives From S.Hookeriana 143
4 3 Part B( Bioprospecting Studies On Sonchus Wightianus ) 156
8506.49 KB
  3.1 Introduction 157
  3.2 Results And Discussion 159
  3.3 Experimental 164
  3.4 Biological Activities On S. Wightianus 170
5 4 Part C ( Bioprospecting Studies On Paris Polyphlla ) 173
12927.21 KB
  4.1 Introduction 174
  4.2 Results And Discussion 176
  4.3 Experimental 183
  4.4 Biological Evaluations 192
6 5 Part D ( Bioprospecting Studies On Tinospora Cordifolia ) 197
6163.95 KB
  5.1 Introduction 198
  5.2 Results And Discussion 200
  5.3 Experimental 203
  5.4 Antioxidant Studies 208
7 6 References 210
6199.88 KB
8 7 Glossary 218
42.68 KB
9 8 List Of Publications 222
21.94 KB