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BIOPROSPECTING STUDIES ON SARCOCOCCA HOOKERIANA BAIL., SONCHUS WIGHTIANUS DC, PARIS POLYPHYLLA SMITH AND RELATED MEDICAL PLANTS OF NEPAL

Devkota, Krishna Prasad (2005) BIOPROSPECTING STUDIES ON SARCOCOCCA HOOKERIANA BAIL., SONCHUS WIGHTIANUS DC, PARIS POLYPHYLLA SMITH AND RELATED MEDICAL PLANTS OF NEPAL. PhD thesis, University of Karachi, Karachi.

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Abstract

This Ph. D. dissertation is divided into four parts, focusing on the bioprospecting studies on four medicinally important plants of Nepalese origin. Part B of the thesis contains the b oprospectig studies on sonchus wightinaus DC. That resulted in the isolation of five known secondary metabolites. The isolation was carried out by following the results of acetyl-cholinesterase inhibition assays and phytotoxicity assay on Lemna minor. Most of the fractions were found to be active in the bioassay screenings. The known compounds were identified as β-amyrin (18), β-amyrin acetate(19), β-amyrinone(20), β-sitosterol (21), and β-sitosterol glucoside(22). Part C describes the bioprospecting study on paris polyphylla smith. During this study, six known compounds przewalskinone B (23), polyphyllin-C(24), polyphyllin-D(25), saponin-1 (26), stigmasterol(27) glucoside(28) were obtained. The tyrosinase inhibitory, antilieshmanial and cytotoxicity (on human neutrophils) assays were carried out on these compounds. Part D. This part includes the results of phytochemical study on a medicinal plant, tinospora cordifolia miers., which afforded three known compounds, cycloeuphhordenol(29), 1-cyclohexy1-11-heneicosanone(30). Most of the fractions of the plant extract as well as compound 31 showed potent to moderate antioxidant activities.

Item Type:Thesis (PhD)
Uncontrolled Keywords:sarcococca hookeriana bail., sonchus wightianus dc, paris polyphylla smith, medical plants, nepal, bioprospecting studies, steroidal alkaloids, terminaline (10), chonemorphine (11), n-methylpachysamine-a(12), dictyophelbine(13), salignamide-a(14), sarcovagine-d(16), na-methylepipachysamine-d(17), przewalskinone b (23), polyphyllin-c(24), polyphyllin-d(25), saponin-1 (26), stigmasterol(27) glucoside(28), cycloeuphhordenol(29), 1-cyclohexy1-11-heneicosanone(30), β-amyrin (18), β-amyrin acetate(19), β-amyrinone(20), β-sitosterol (21), β-sitosterol glucoside(22), tinospora cordifolia, paris polyphlla
Subjects:Physical Sciences (f) > Chemistry(f2)
ID Code:1120
Deposited By:Mr. Muhammad Asif
Deposited On:03 Jan 2007
Last Modified:04 Oct 2007 21:04

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