Pakistan Research Repository


Muhammad, Riaz (2001) PHYTOCHEMICAL INVESTIGATIONS ON DAPHNE OLEOIDES. PhD thesis, University of Karachi, Karachi.



The art healing has its origin from the antiquity of human civilization. Man, as a savage, must have known by experience how to relieve his sufferings by the use of herbs growing around him. The historical survey of traditional medicinal reveal that in his search for food the primitive men began to distinguish those plants suitable for nutritional purposes from other possessing definite pharmacological actions. Thus the drugs from the plant origin have served through the ages as mainstay for the treatment of ailments and preservations of human health. A large reservoir of the plant based medicines has been provided in the early period covering the Indians, Chinese, Sumarian, Egyptian, Assyrian and Muslim civilizations. In the Indo-Pak sub-continent studies in the chemical constituents of indigenous medicinal plants have been carried out at various research centers to serve the dual purposes of broadening pharmacopial spectrum and providing a base for the therapeutical study directed towards the syntheses of drugs modeled on chemical structure of natural products. In this context it is of special interest of to note that the largest and the most sophisticated nucleus for the systematic investigation in the chemistry of biologically active principles of indigenous medicinal plants is based at Karachi under the name of H.E.J. Research Institute of Chemistry, which is presently under the directorship of famous plant Chemist of Pakistan, Professor Atta-ur-Rehman The present doctoral dissertation describes the phytochemical investigations on Daphne oleoides which have resulted in the isolation and structure elucidation of nine new natural products including four dimeric coumarin glycosides (1-4), two trimeric coumarin glycosides (5-6), one furanoid lignan glycoside (7) and two furofuranoid, glycosides (8-9) Furthermore, fifteen new source or known compounds, including seven coumarins (10-16), two lignans (17-18), syringin (19), three terpenoids (20-22) and two steroids (23-24), have also been isolated and characterized

Item Type:Thesis (PhD)
Uncontrolled Keywords:daphne oleoides, dimeric coumarin glycosides, trimeric coumarin glycosides, furanoid lignan glycoside, furofuranoid, glycosides, coumarins, lignans, syringin, terpenoids, steroids
Subjects:Physical Sciences (f) > Chemistry(f2)
ID Code:1100
Deposited By:Mr. Muhammad Asif
Deposited On:20 Dec 2006
Last Modified:04 Oct 2007 21:04

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