I= ISOLATION AND STRUCTURAL STUDIES ON THE CHEMICAL CONSTITUENTS OF BUXUS SPECIES
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Title of Thesis
ISOLATION AND STRUCTURAL STUDIES ON THE CHEMICAL CONSTITUENTS OF BUXUS SPECIES

Author(s)
Dildar Ahmed
Institute/University/Department Details
University of Karachi/ H.E.J. Research Institute of Chemistry
Session
1990
Subject
Chemistry
Number of Pages
140
Keywords (Extracted from title, table of contents and abstract of thesis)
buxus species, buxus sempervirens, buxus alkaloids, alkaloids, flavonoids

Abstract
Studies on the chemical constituents of the leaves of Buxus sempervirens have led to the isolation of seven new steroidal alkaloids and a new flavonoid glycoside. In addition, seven other alkaloids and two flavonoids have also been isolated. Modern spectroscopic techniques were employed to determine the structures of the compounds

A new system of nomenclature has been established from Buxus alkaloids which gives considerable short and easy names. This has been described in the introduction section.

I. New alkaloids 1. (-)-Sempervirone J. nat.prod. , 51, 783 (1988) 2. (-)-A-Buxenone Planta med., 54, 173 (1988) 3. (-)-cyclomicrobuxamine Fitoapia, 5, 439 (1989) 4. (+)-Acetylbuxanoldine Fitoterapia, 5, 439 (1989) 5. (+)-Semperviramidine Phytochemistry, 27, 2367 (1988) 6. (-)-Buxadienine Phytochemistry, 28, 1293 (1989) 7. (-)-31-Acetycyclomicrophylline-A Phytochemistry (accepted) II. Known alkaloids unreported from B. Semperviens 1. (-)-E-Cyclosufforbuxinine J.Nat.Prod. , 51 783 (1988) 2. (-)-A-Cycolsufforbuxinine 3. (+)-Buxaquaramarine Phytochemistry, 28, 1293 (1989) 4. (-)-16a-Acetoxybuxabenzamidienine Phytochemistry, 27, 2367 (1988) 5. (-)-31-Acetoxy-Na-benzoylbuxidienine Phytochemistry, 28, 1293 (1989) 6. (-)-Cyclomicrophylline-A J.Nat. Prod. (accepted) 7. (-)-Cyclomirobuxinine J.Nat.Prod. 51, 783 (1988) III Known alkaloids 1. (+)-Buxaminol-E 2. (-)-E-Buxenone Planta Med., 54, 173 (1988) 3. (+)-N-benzoylcycloxobuxine-F 4. (+)-N-Benzoyl-O-acetylcycloxobuxoline-F 5. (+)-Buxpsiine J.Nat.Prod. , (accepted) IV. A new flavonoid Glycoside, (-)-Galactobuxin J.Nat.Prod., (accepted) V. Known flavonoids 1.4’, 5-Dihydroxy-3,3’6,7-tetramethoxyflavone Planta Med., 54, 173 (1988) 2. Artemetin Planta Med., 54, 173 (1988).

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S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
50.73 KB
2 1 General Introduction 4
45.09 KB
3 2 Introduction 8
194.84 KB
  2.1 Buxus alkaoids 9
  2.2 Alavonoids 28
  2.3 Buxus sempervirens 36
4 3 Results and Discussion 39
446.16 KB
  3.1 New alkaloids 40
  3.2 Known alkaloids unreported from buxus sempervirens 69
  3.3 Reported alkaloids 81
  3.4 A new flavonoid glycoside (-)- Galactobuxin (76) 94
  3.5 Known flavonoids unreported from B. Sempervirens 102
5 4 experimental 107
192.75 KB
  4.1 General Experimental conditiosns 108
  4.2 Plant material 110
  4.3 Extraction and Purification 110
  4.4 Compounds from the leaves of B.Sempervirens 110
6 5 References 131
62.19 KB
7 6 List of Publication 139
15.35 KB