I= ISOLATION AND STRUCTURAL STUDIES ON THE CHEMICAL CONSTITUENT OF MEDICAL PLANTS SKIMMIA LAUREOLA AND WITHANIA COAGULANTS
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Title of Thesis
ISOLATION AND STRUCTURAL STUDIES ON THE CHEMICAL CONSTITUENT OF MEDICAL PLANTS SKIMMIA LAUREOLA AND WITHANIA COAGULANTS

Author(s)
Muhammad Yousaf
Institute/University/Department Details
H.E.J. Research Institute of Chemistry/ University of Karachi
Session
1998
Subject
Chemistry
Number of Pages
229
Keywords (Extracted from title, table of contents and abstract of thesis)
medical plants, skimmia laureola, withania coagulants, ergostane-type steroids, terpenes, coumarins, quinoline alkaloids

Abstract
This dissertation describes the phytochemical investigations one the two medicinally important plant of Pakistan namely Withania Coagulans and Skimmia Laureola.

Phytochemical studies on the whole plant of W. coagulans have led to the isolation often new withanolides,(+)-coagulin F (48) (+)-coagulin H (49), (+)-coagulin I (50), (+)-coagulin J(51), (+)-coagulin K(52), (+)-coagulin L(53), (+)-coagulin M(54), (+)-coagulin N(55), (+)-coagulin O(56), (+)-coagulin P(57)

(48) J.Nat. Prod., 1998,61,812-814 (49)Heterocycles, 1998,48,1801-1811. (50)Heterocycles,1998,48,1801-1811. (51) Heterocycles,1998,48,1801-1811. (52) Heterocycles,1998,48,1801-1811. (53) Heterocycles,1998,48,1801-1811. (54) Chem. Pharm.Bull., 1998(in press) (55) Chem. Pharm.Bull., 1998(in press) (56) Chem. Pharm.Bull., 1998(in press) (57)Heterocycles, 1998(Submitted)

Studies on the chemical constituents of Skimmia Laureola have yielded a triterpendiod (+)-taraxerone (82), three coumarins (+)-Oxypeucedanin hydrate(83), (+)-ulopterol(84), 2-H-1-benzopyrane-2-one(68), two esters: (E)-3’-(4-hydroxypheny1)-2’propenoic methyl ester(85), (E)-3’-(4-hydroxypheny1)-2’propenoic methyl ester(86), and two quinoline alkaloids: (+)-edulinine(87) and (±)-ribalinine(88). Compounds 82-88 have been isolated for the first time from this source compounds 68,84 and 88 have shown antimicrobial activities against a number of human pathogenic bacteria and fungi. The structure of (+)-taraxerone (82)was unambiguously identified by single-crystal X-ray diffraction methods.

The structure of these new and known natural product were determined on the basis of extensive spectroscopic studies including one-, two- and inverse two dimensional NMR experiments (such as COSY, HOHAHA, HMQC HMBC etc.) chemical dramatizations.

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S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
75.83 KB
2 1 Withania Coagulans 1
2027.22 KB
  1.1 Withanloides And Related Ergostane -Type Steroids 2
  1.2 Phytochemical Studies On Withania Coagulans 20
  1.3 Experimental 158
3 2 Skimmia Laureola 181
491.89 KB
  2.1 Terpenes 181
  2.2 Coumarins 183
  2.3 Quinoline Alkaloids 184
  2.4 Results And Discussion 185
  2.5 Experimental 208
4 3 References 219
77.72 KB
5 4 Glossary 227
24.16 KB
6 5 List Of Publications 229
12.83 KB
7 6 Publications Resulted From This Work 230
425.08 KB