I= SYNTHESIS AND CHARACTERIZATION OF ORGANOTIN (IV) COMPLEXES WITH DONOR LIGANDS
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Title of Thesis
SYNTHESIS AND CHARACTERIZATION OF ORGANOTIN (IV) COMPLEXES WITH DONOR LIGANDS

Author(s)
Wajid Rehman Gora
Institute/University/Department Details
Gomal University Dera Ismail Khan/ Department of Chemistry
Session
2005
Subject
Chemistry
Number of Pages
124
Keywords (Extracted from title, table of contents and abstract of thesis)
organotin, ligands, halides, bacteria, bacillus subtills, stapholococcus aureus, escherichia coli, schigella flexenari, pseudomonas aeruginosa, salmonella typh, fungi, c.capsici, c.glocosporiodes, a. brassicicola, a brassicae, h. graminium, metallic tin, organotin carboxylates

Abstract
Organotin(IV) complexes with the general formulae RnSnL4-n and RnSn2Ln (R=alkyl, L =monomethyl glutarate, monomethyl phthalate, monomethyl (2-Phenyl glutarate) and Schiff bases of 2-aminophenol and salicylaldehyde) have been prepared.

These complexes have been synthesized by the reaction of organotin(V) complexes have been synthesized by the reaction of organotin(IV) oxide with the ligand. The reaction of organotin (IV) oxide with the ligand. The reaction is carried out at the reflux trmperature of benzene while water formed during the reaction is continuously removed by means of a Dean and Stark apparatus.

The reaction fo organotin(IV) oxides with organic ocids is more economical and gives better purities as the reaction of organotin(IV) halides with organic acids in the presence of a base.

These complexes have been characterized by elemental analyses and molar conductivity. The chemical bonding in these complexes have been discussed in terms of their IR, 1H-, 13 C and 119Sn-NMR, mass and 119Sn-Mossbauer spectral studies

The 1H and 13C chemical shift assignments of the organotin moiety are straightforward from the multiplicity and intensity pattern, whereas the ligand skeletons were assigned by multiplicity pattern and/or resonance intensities of signals as well as their coupling constants. The alkyl groups attached shifts with those calculated from incremental methods or compared to the literature data

The monomeric 1:1 complexes have trigonal bipyramidal geometry with cisequitorial organic groups, the dimeric 1:2 complexes have octahedral geometry while complexes derived from a Schiff base of 2-aminphenol and salicyladehyde have tetrahedral geometries

Mass spectrum analyses reveal that the primary decomposition is due to the loss of a ligand in case of diorganotin(IV) complexes along with the successive elimination of a CO2 molecule while in triorganotin(IV) complexes the primary decomposition is due to the loss of an alkyl group along with the elimination of a CO2 molecule

The geometry assigned to these complexes is well supported by infrared and Mossauer studies

All these complexes, soluble in DMSO and DMF have been screened against a wide spectrum of bacteria (Bacillus subtills, Stapholococcus aureus, Escherichia coli, Schigella flexenari, Pseudomonas aeruginosa, and Salmonella typh) and fungi (C.capsici, C.glocosporiodes, A. brassicicola, A brassicae, H. graminium. The ALD50 values have been determined with albino rats. Some of the complexes exhibited very high anti-inflammatory activities. The cytostatic activity of the complexes exhibited very high anti-inflammatory activities. The cytostatic activity of the complexes has been assayed against the established cell line KB, which has been derived from a human oral epidermoid carcinoma. The results obtained are quite promising

Overall, triorganotin(IV) derivatives exhibit significantly better activities than the diorganotin(IV) complexes

Download Full Thesis
1118.68 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
112.54 KB
2 1 Introduction 1
173.56 KB
  1.1 Occurrence 3
  1.2 Physical Properties Of Metallic Tin 3
  1.3 Chemical Properties 7
  1.4 Organotin Compounds 7
  1.5 Synthesis Of Organotin ( Iv) Compounds 8
  1.6 Organotin Esters Of Organic And Lnorganic Acids 10
  1.7 Organotin Carboxylates 10
  1.8 Organotin( Iv) Schiff Bases 11
  1.9 Physical Properties And Structure 13
  1.10 Reactions 17
3 2 Biological & Industrial Applications Of Organotin Compounds 21
140.36 KB
  2.1 Toxicity Pattern And Mode Of Biological Action 21
  2.2 Biological Applications (R3snx Compounds ) 24
  2.3 Non Biocidal Uses (R2snx3 Compounds ) 32
4 3 Experimental/Summary 35
382.91 KB
  3.1 Chemicals 36
  3.2 Instrumentation 36
  3.3 General Procedures For Syntheses 37
  3.4 Physical Data 38
  3.5 Ligand 2 ( Monomethyl Phthalate ) 46
  3.6 Ligand 3 (2-Phenyl Monomethyl Glutarate ) 54
  3.7 Ligand 4 (Schiff Abse Derived From 2-Aminophenol And Salicylaldehyde ) 64
  3.8 Biological Studies 68
5 4 Results And Discussion 71
475.87 KB
  4.1 Structural Studies 71
  4.2 Biological Activity 88
  4.3 Refernces 107
  4.4 List Of Publications 124